bs-82313C
[Life Science]
ISRIB
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6
Description:
CAS Number: 1597403-47-8<br></br>Chemical Name: N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide<br></br>Molecular weight: 451.34<br></br>Formula: C22H24Cl2N2O4 <br></br>Solubility: DMSO (5 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.