bs-82299C
[Life Science]
KU-55933
DATASHEET
Formulation Dark red-brown solid
Storage: -20°C
Product Information:
Potent and selective ATM kinase inhibitor IC50s= 13, 2500, 9300, 16600, >100000 and >100000 nM for ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively.1 Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21CIP1 levels in vitro.2 Disruption of ATM signaling in primary A-T fibroblasts leads to dysregulation of ribonucleotide reductase and increase resistance to inhibitors of mitochondrial respiration and translation.3 Sensitizes radio-resistant cancer cells.4 Provides neuroprotection against H2O2-induced cell damage.5
Description:
CAS Number: 587871-26-9<br></br>Chemical Name: 2-(4-Morpholinyl)-6-(1-thiamthrenyl)-4H-pyran-4-one<br></br>Molecular weight: 395.50<br></br>Formula: C21H17NO3S2<br></br>Solubility: DMSO (40 mg/ml) Ethanol (20 mg/ml)<br></br>Physical Properties: Tan solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.