bs-82270C
[Life Science]
PRT4165
DATASHEET
Formulation White solid
Storage: RT
Product Information:
Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2
Description:
CAS Number: 31083-55-3<br></br>Chemical Name: 2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione<br></br>Molecular weight: 235.24<br></br>Formula: C15H9NO2<br></br>Solubility: DMSO (25 mg/ml) Ethanol (6 mg/ml)<br></br>Physical Properties: Yellow solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.