bs-82267C
[Life Science]
MitoBloCK-6
DATASHEET
Formulation Off-white solid
Storage: -20°C
Product Information:
Inhibits redox-regulated protein translocation into mitochondria. It attenuates the import of Erv1 substrates by inhibition of Erv1 oxidase activity (the import of Tim23 and AAC was decreased by ~50% at 20 μM). MitoBloCK-6 elucidated an unexpected role for Erv1 in the carrier import pathway, namely transferring substrates from the translocase of the outer membrane complex into the small Tim complexes. It impaired cardiac development in zebrafish embryos and induced apoptosis via the release of cytochrome c in human embryonic stem cells but not differentiated cells1.
Description:
CAS Number: 303215-67-0<br></br>Chemical Name: 2-[[(4-Anilinophenyl)imino]methyl]-4,6-dichlorophenol<br></br>Molecular weight: 357.24<br></br>Formula: C19H14Cl2N2O<br></br>Solubility: DMSO (50 mg/ml) ethanol (6 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.