bs-82245C
[Life Science]
680C91
DATASHEET
Formulation White solid
Storage: -20°C
Product Information:
A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM)1,2. Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal2. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand4.
Description:
CAS Number: 163239-22-3<br></br>Chemical Name: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole<br></br>Molecular weight: 238.27<br></br>Formula: C15H11FN2 <br></br>Solubility: DMSO (20 mg/ml) Ethanol (10 mg/ml)<br></br>Physical Properties: Light brown solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.