bs-82219C
[Life Science]
GSK-J4
DATASHEET
Formulation Pale yellow solid
Storage: -20°C
Product Information:
Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
Description:
CAS Number: 1373423-53-0<br></br>Chemical Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester<br></br>Molecular weight: 417.48<br></br>Formula: C24H27N5O2<br></br>Solubility: DMSO (40 mg/ml) Ethanol (40 mg/ml)<br></br>Physical Properties: Yellow waxy solid<br></br>Purity: 99% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.