bs-82218C
[Life Science]
GSK-J1
DATASHEET
Formulation Tan solid
Storage: RT
Product Information:
Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.
Description:
CAS Number: 1373422-53-7<br></br>Chemical Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine<br></br>Molecular weight: 389.46<br></br>Formula: C22H23N5O2<br></br>Solubility: DMSO (20 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 99% by TLC, NMR (Conforms)
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.