DATASHEET
Formulation
Tan solid
Storage:
-20°C
Product Information:
Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM)1. Inhibits ER stress-induced neuronal damage2. Reduces brain PKR activation in vivo3. Prevents apoptosis and IL-1β production in an acute excitotoxic and neuroinflammatory rat model4. Prevents β-amyloid peptide-induced inflammation in primary murine mixed co-cultures5. Cell permeable.
Description:
CAS Number: 608512-97-6<br></br>Chemical Name: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one<br></br>Molecular weight: 268.30<br></br>Formula: C13H8N4OS<br></br>Solubility: DMSO (15 mg/ml)<br></br>Physical Properties: Orange solid<br></br>Purity: 98% by TLC, NMR Conforms