bs-82152C
[Life Science]
6-Thioguanine
DATASHEET
Formulation Tan solid
Storage: -20°C
Product Information:
After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.
Description:
CAS Number: 154-42-7<br></br>Chemical Name: 2-Amino-6-mercaptopurine<br></br>Molecular weight: 167.19<br></br>Formula: C5H5N5S<br></br>Solubility: DMF (1.5 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 96% by HPLC NMr (Conforms)
Size: 100 mg, 1 g100 mg, 1 g
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.