bs-82149C
[Life Science]
5-Fluorouracil
DATASHEET
Formulation White or off-white solid
Storage: -20°C
Product Information:
5-Fluorouracil (5-FU) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-FU are 5-Fluorodeoxyuridylate (5-FdUMP), 5-Fluorodeoxyuridine triphosphate (5-FdUTP) and 5-Fluorouridine triphosphate (5-FUTP). The primary cytotoxic effect of 5-FU is believed to be inhibition of thymidylate synthase by 5-FdUMP. Secondary effects include incorporation of 5-FdUTP into DNA resulting in DNA strand breaks and incorporation of 5-FUTP into RNA causing abnormal RNA processing.1
Description:
CAS Number: 51-21-8<br></br>Chemical Name: 5-Fluoro-1H,3H-pyrimidine-2,4-dione<br></br>Molecular weight: 130.08<br></br>Formula: C4H3FN2O2<br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: 98%
Size: 250 mg, 1 g250 mg, 1 g
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.