DATASHEET
Formulation
Yellow solid
Storage:
-20°C
Product Information:
Thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs).1,2 Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition.3 Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages.4
Description:
CAS Number: 3056-17-5<br></br>Chemical Name: 2’,3’-Didehydro-3’-deoxythymidine<br></br>Molecular weight: 224.22<br></br>Formula: C10H12N2O4<br></br>Solubility: DMSO (20 mg/ml) Water (20 mg/ml)<br></br>Physical Properties: White solid<br></br>Purity: >98% by HPLC, NMR (conforms)