bs-82134C
[Life Science]
Xestospongin C
DATASHEET
Formulation Yellow solid
Storage: -20°C
Product Information:
A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM1. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+ and K+ currents at a concentration range similar to that at which it inhibits the IP3 receptor. It is a useful tool for probing the involvement of IP3 receptors in cellular signaling3. Cell permeable.
Description:
CAS Number: 88903-69-9<br></br>Chemical Name: Natural product isolated from the marine sponge Xestospongia sp.<br></br>Molecular weight: 446.71<br></br>Formula: C28H50N2O2 <br></br>Solubility: DMSO (10 mg/ml)<br></br>Physical Properties: Lyophilized solid<br></br>Purity: 97% by TLC NMR (Conforms)
Size: 10 ug, 50 ug10 ug, 50 ug
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.