bs-82123C
[Life Science]
PIT-1
DATASHEET
Formulation light yellow solid
Storage: RT
Product Information:
PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
Description:
CAS Number: 53501-41-0<br></br>Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide<br></br>Molecular weight: 351.76<br></br>Formula: C14H10ClN3O4S<br></br>Solubility: DMSO (25 mg/ml) Ethanol (3 mg/ml)<br></br>Physical Properties: Grey solid<br></br>Purity: 98% by TLC, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.