DATASHEET
Formulation
Purple solid
Storage:
-20°C
Product Information:
A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the and subunits and not the AMP binding site1. EC50=0.8 M for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 M2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.
Description:
CAS Number: 844499-71-4<br></br>Chemical Name:
4-Hydroxy-3-(2’-hydroxy-[1,1’-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
<br></br>Molecular weight: 360.39<br></br>Formula: C20H12N2O3S<br></br>Solubility: DMSO (30 mg/ml) Ethanol (5 mg/ml)<br></br>Physical Properties: Beige solid<br></br>Purity: 98% by HPLC, NMR (Conforms)