bs-82105C
[Life Science]
KB-R7943 mesylate
DATASHEET
Formulation Colorless oil
Storage: RT
Product Information:
KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50’s = 1.2-2.4 µM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7µM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) – Ki = 5.5 µM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 µM) and block NMDA receptors (IC50 = 13.4 µM).4
Description:
CAS Number: 182004-65-5<br></br>Chemical Name: 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioures mesylate<br></br>Molecular weight: 427.49<br></br>Formula: C16H17N3O3S ∙ CH3SO3H<br></br>Solubility: DMSO (50 mg/ml)<br></br>Physical Properties: Tan solid<br></br>Purity: 98% by TLC [ 10% methanol in methylene chloride + 0.1% NH4OH; Rf = 0.40] NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.