bs-82065C
[Life Science]
Zileuton
DATASHEET
Formulation white solid
Storage: -20°C
Product Information:
Zileuton is a reversible inhibitor (IC50 = 500nM RBL-1 cells, 300nM rat PMNL cells) of 5-Lipoxygenase (5-LO).1 It also inhibited leukotriene B4 biosynthesis (IC50’s = 400nM rat PMNL, 400nM human PMNL and 900nM human whole blood).1 Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 µM PGE2 inhibition in LPS-stimulated whole blood).2 Zileuton was approved by the FDA in 1997 for the treatment of asthma (ZYFLO).
Description:
CAS Number: 111406-87-2<br></br>Chemical Name: N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea<br></br>Molecular weight: 236.29<br></br>Formula: C11H12N2O2S<br></br>Solubility: DMSO (25 mg/ml)<br></br>Physical Properties: white solid<br></br>Purity: >98%, NMR (Conforms)
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.