bs-82062C
[Life Science]
AG-490
DATASHEET
Formulation Tan solid
Storage: -20°C
Product Information:
A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.
Description:
CAS Number: 133550-30-8<br></br>Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N¬-(phenylmethyl)-2-propenamide<br></br>Molecular weight: 294.31<br></br>Formula: C17H14N2O3<br></br>Solubility: DMSO (25 mg/ml) DMF (40 mg/ml) Ethanol (10 mg/ml)<br></br>Physical Properties: Tan solid<br></br>Purity: 98% by TLC [ 10% methanol in methylene chloride, Rf = 0.50] NMR Conforms
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.