DATASHEET
Formulation
Tan solid
Storage:
-20°C
Product Information:
Mirin is an inhibitor of the Mre11-Rad50-Nbs1(MRN) complex (IC50 = 12 µM for inhibition of ATM activity), part of the MRN-ATM(ataxia-telangiectasia mutated) pathway, an essential pathway for sensing and signaling from DNA double-strand breaks. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells.
Description:
CAS Number: 299953-00-7<br></br>Chemical Name: 5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one<br></br>Molecular weight: 220.25<br></br>Formula: C10H8N2O2S<br></br>Solubility: DMSO (30 mg/ml)<br></br>Physical Properties: Tan solid<br></br>Purity: 98% by TLC, NMR Conforms