bs-82021C
[Life Science]
AAL-993
DATASHEET
Formulation Pale yellow solid
Storage: RT
Product Information:
Inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-ß, cKit, and CSF-1R are also inhibited at higher concentrations (IC50’s 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies.
Description:
CAS Number: 269390-77-4<br></br>Chemical Name: 2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide<br></br>Molecular weight: 371.36<br></br>Formula: C20H16F3N3O<br></br>Solubility: DMSO (25 mg/ml) Ethanol (15 mg/ml)<br></br>Physical Properties: Pale yellow solid<br></br>Purity: 98% by TLC [60% ethyl acetate in hexane; Rf = 0.36] NMR conforms
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.