bs-82005C [Life Science]
Arecoline HBr
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Formulation White solid

Storage: RT

Product Information:

Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50 in the range of 7-410 nM).2 May be effective in dementia.3

Description:

CAS Number: 300-08-3<br></br>Chemical Name: 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide<br></br>Molecular weight: 236.11<br></br>Formula: C8H13NO2 HBr <br></br>Solubility: Water (50 mg/ml) <br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC, NMR (Conforms)

Size: 250 mg, 1 g250 mg, 1 g

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.