DATASHEET
Formulation
White solid
Storage:
RT
Product Information:
Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50 in the range of 7-410 nM).2 May be effective in dementia.3
Description:
CAS Number: 300-08-3<br></br>Chemical Name: 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide<br></br>Molecular weight: 236.11<br></br>Formula: C8H13NO2 HBr <br></br>Solubility: Water (50 mg/ml) <br></br>Physical Properties: White solid<br></br>Purity: 98% by TLC, NMR (Conforms)