bs-80499C
[Life Science]
ß-Lapachone
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:242.27
Formula:C15H14O3
Purity:>98%
Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Chemical Name:3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Formula:C15H14O3
Purity:>98%
Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Chemical Name:3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Description:
A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.