bs-80498C
[Life Science]
Halofuginone HBr
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:495.6
Formula:C16H17BrClN3O3 • HBr
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml)
Chemical Name:(2R,3S)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
Formula:C16H17BrClN3O3 • HBr
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml)
Chemical Name:(2R,3S)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide
Description:
Potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine1. Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and inhibiting fibroblast differentiation2. Blocks fibrosis, angiogenesis, and tumor progression2,3. Inhibition of PRS results in amino acid starvation which activates the integrated stress response (ISR) and mTOR signaling4 and thus preventing differentiation of TH17 cells, suppressing the autoimmune response5. Reduces TMPRSS2 protein levels via enhanced ubiquitination and proteasomal degradation, limiting SARS-CoV-2 cellular entry6.
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.