DATASHEET
Formulation
powder
Storage:
RT
Product Information:
Molecular Weight:270.21
Formula:C12H9F3N2O2
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml).
Chemical Name:5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Description:
A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2. Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide.
Rescues mice from acetaminophen-induced liver injury3.