bs-80480C
[Life Science]
Pirfenidone
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:185.23
Formula:C12H11NO
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml)
Chemical Name:5-Methyl-1-phenyl-2(1H)-pyridinone
Formula:C12H11NO
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml)
Chemical Name:5-Methyl-1-phenyl-2(1H)-pyridinone
Description:
Antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes.2 Up-regulates RGS2 (Regulator of G-protein Signaling 2) which represents a new mechanism of pirfenidone action.3 Inhibits fibroblast proliferation.4 Suppresses TNFα production at the translational level.5 Scavenges hydroxyl radicals and inhibits lipid peroxidation in a dose-dependent manner.6 Recently approved therapeutic agent for idiopathic pulmonary fibrosis.7 Orally active.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.