bs-80446C
[Life Science]
Picropodophyllotoxin
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:414.42
Formula:C22 H22 O8
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml).
Chemical Name:(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro¬-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7¬]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Formula:C22 H22 O8
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml).
Chemical Name:(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro¬-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7¬]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Description:
Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP1. Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM1. Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 M2. Exhibits antiangiogenic activitiy3. Attenuates intimal hyperplasia after vascular injury4. Active in vivo.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.