bs-80443C
[Life Science]
Vatalanib 2HCl
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:419.73
Formula:C20H15ClN4 2HCl
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
Chemical Name:N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Formula:C20H15ClN4 2HCl
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
Chemical Name:N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Description:
Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM)1. Weaker inhibitor of other tyrosine kinases including PDGFR-β (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 µM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC50 > 10 µM). Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.