bs-80431C
[Life Science]
Lenalidomide
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:259.26
Formula:C13H13N3O3
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml).
Chemical Name:(R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
Formula:C13H13N3O3
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml).
Chemical Name:(R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
Description:
Thalidomide analog which, like thalidomide,1 binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation2. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death3,4. Cell permeable. Caution: Teratogenic
Size: 100 mg, 500 mg100 mg, 500 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.