bs-80429C
[Life Science]
Irinotecan HCl
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:586.69 ∙ 36.46 ∙ 54.05
Formula:C33H38N4O6 ∙ HCl ∙ 3H20
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
Chemical Name:(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’-bipiperidine]-1’-carboxylate hydrochloride
Formula:C33H38N4O6 ∙ HCl ∙ 3H20
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
Chemical Name:(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3’,4’:6,7]-indolizino[1,2-b]quinolin-9-yl-[1,4’-bipiperidine]-1’-carboxylate hydrochloride
Description:
Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
Size: 50 mg, 250 mg50 mg, 250 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.