bs-80427C
[Life Science]
GW-2580
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:366.32
Formula:C20H22N4O3
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml).
Chemical Name:5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Formula:C20H22N4O3
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml).
Chemical Name:5-(3-Methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine
Description:
Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 μM)1. Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.