bs-80424C
[Life Science]
Erlotinib HCl
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:429.91
Formula:C22H23N3O4 · HCl
Purity:>98%
Solubility:Soluble in DMSO (up to 18 mg/ml with warming).
Chemical Name:N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
Formula:C22H23N3O4 · HCl
Purity:>98%
Solubility:Soluble in DMSO (up to 18 mg/ml with warming).
Chemical Name:N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
Description:
Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM)1. Potent inhibitor of mutant JAK2-V617F2. Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) ErbB-4 kinase (Ki = 1.5 μM)3. HDAC inhibitors sensitize for erlotinib activity in EGFR-mutated and wildtype non-small cell lung cancer (NSCLC) cells4. A clinically effective agent for NSCLC5.
Size: 10 mg, 100 mg10 mg, 100 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.