bs-80421C
[Life Science]
Enzastaurin
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:515.61
Formula:C32H29N5O2
Purity:>98%
Solubility:Soluble in DMSO (up to 7 mg/ml with warming)
Chemical Name:3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Formula:C32H29N5O2
Purity:>98%
Solubility:Soluble in DMSO (up to 7 mg/ml with warming)
Chemical Name:3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
Description:
Potent and selective PKCβ inhibitor. IC50 = 6, 39, 83 and 110 nM, for PKCβ, PKCα, PKCγ and PKCε respectively.1 Induces apoptosis in multiple myeloma cell lines via inhibition of the AKT signaling pathway.2 Induces mitotic missegregation and preferential cytotoxicity in colorectal cancer cells with chromosomal instability.3 Attenuates ampheta-mine-stimulated dopamine efflux.4 Inhibits blood-brain barrier leakiness in a mouse model.5
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.