bs-80420C
[Life Science]
Dovitinib
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:392.4
Formula:C21H21FN6O
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml).
Chemical Name:4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
Formula:C21H21FN6O
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml).
Chemical Name:4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one
Description:
Potent receptor tyrosine kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM)1. Selectively blocks growth B9 cells transformed by wild type or activated mutant FGFR32. Induces autophagy and apoptosis in human breast cancer cells by regulating SHP-1-dependent STAT3 inhibition3. Also enhances BMP-2-induced osteoblast differentiation in mouse myoblast cells4. Clinically useful cancer treatment5.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.