bs-80401C
[Life Science]
Myriocin (ISP-1)
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:401.54
Formula:C21H39NO6
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml).
Chemical Name:(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
Formula:C21H39NO6
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml).
Chemical Name:(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
Description:
Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.