bs-80394C
[Life Science]
Gliotoxin
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:326.4
Formula:C13H14N2O4S2
Purity:>98%
Solubility:Soluble in DMSO (up to 15 mg/ml)
Chemical Name:(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
Formula:C13H14N2O4S2
Purity:>98%
Solubility:Soluble in DMSO (up to 15 mg/ml)
Chemical Name:(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
Description:
A fungal metabolite with immunosuppressive properties: blocks phagocytosis, cytokine production and proliferation of T and B cells1. Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4. Inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells5.
Size: 1 mg, 5 mg 5 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.