bs-80380C
[Life Science]
DRB
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:319.14
Formula:C12H12Cl2N2O4
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml)
Chemical Name:5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
Formula:C12H12Cl2N2O4
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml)
Chemical Name:5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
Description:
A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 μM. 3 Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.