bs-80376C
[Life Science]
Itraconazole
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:705.6
Formula:C35H38Cl2N8O4
Purity:>98%
Solubility:Soluble in DMSO (up to 1.5 mg/ml with warming)
Chemical Name:
Formula:C35H38Cl2N8O4
Purity:>98%
Solubility:Soluble in DMSO (up to 1.5 mg/ml with warming)
Chemical Name:
Description:
Itraconazole inhibits the conversion of lanosterol to ergosterol via inhibition of the 14-α demethylase, a cytochrome P-450 enzyme1. Clinically useful antifungal agent. It inhibits the proliferation of glioblastoma cells in vitro and in vivo by inducing autophagic progression via inhibiting the trafficking of cholesterol from late endosomes and lysosomes to the plasma membrane2. Inhibits the hedgehog pathway by binding to Smoothened (SMO) via a mechanism distinct from that of cyclopamine3. Inhibits angiogenesis via inhibiting the binding of VEGF to VEGFR24.
Size: 50 mg, 250 mg50 mg, 250 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.