bs-80365C
[Life Science]
NAcM-OPT
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:434.40
Formula:C23H29Cl2N3O
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml)
Chemical Name:1-Benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea
Formula:C23H29Cl2N3O
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml)
Chemical Name:1-Benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea
Description:
A potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1 It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.