DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:327.1
Formula:C20H22ClNO
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml)
Chemical Name:4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
Description:
A high-affinity RAGE (Receptor for Advanced Glycation End products) antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo1,2. In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage3. It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling4. Attenuates AGE-induced neuroinflammation and oxidative stress in rat microglia5. BBB permeable.