DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:489.32
Formula:C21H21BrN4O5
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml)
Chemical Name:2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
Description:
A potent and selective inhibitor of the autophagy kinase ULK-1, IC50=108 and 711 nM for ULK1 and 2 respectively.1 Suppresses autophagy induced by mTOR inhibitors and thus synergizes with mTOR inhibitors to induce apoptosis and cell death in tumor cells.1