bs-80360C
[Life Science]
RI-1
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:361.61
Formula:C14H11Cl3N2O3
Purity:>98%
Solubility:Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Chemical Name:3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Formula:C14H11Cl3N2O3
Purity:>98%
Solubility:Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Chemical Name:3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
Description:
RI-1 is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.