DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:394.47
Formula:C23H26N2O4
Purity:>98%
Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
Chemical Name:(2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Description:
Potent and selective prostaglandin EP2 receptor antagonist, KB = 2.4 and 34.5 nM for EP2 and DP1 receptors respectively. Displays >500-fold selectivity for EP2 over other prostanoid receptors.1 Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.2 Inhibits PGE2-induced inflammatory response and may represent a novel pharmacologic intervention for tumorigenesis resulting from inflammation.1