bs-80340C
[Life Science]
Dabrafenib (GSK2118436)
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:519.56
Formula:C23H20F3N5O2S
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml with warming).
Chemical Name:N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide
Formula:C23H20F3N5O2S
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 1 mg/ml with warming).
Chemical Name:N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide
Description:
Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.