bs-80335C
[Life Science]
UNC-2170 HCl
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:349.69
Formula:C14H21BrN2O • HCl
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml)
Chemical Name:3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride
Formula:C14H21BrN2O • HCl
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml)
Chemical Name:3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride
Description:
UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.