DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:332.45
Formula:C21H16O4
Purity:>98%
Solubility:Soluble in DMSO (up to 1.5 mg/ml)
Chemical Name:2-(3,2-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
Description:
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). It exhibits antiinflammatory activity including suppression of cytokine-mediated acute phase genes through dissociation of non-dioxin-response element (DRE) AHR activity from DRE-dependent xenobiotic gene expression1. Represses the cytokine-mediated induction of CD55 and therefore may have therapeutic potential in regulating the immune response to tumor formation2. Represses estrogen-inducible transcription3.