bs-80333C
[Life Science]
ML241
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:372.46
Formula:C23H24N4O
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or Ethanol (up to 14 mg/ml with warming)
Chemical Name:N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine
Formula:C23H24N4O
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or Ethanol (up to 14 mg/ml with warming)
Chemical Name:N-Benzyl-2-(2,3-dihydro-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine
Description:
Potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line1. It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1 ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.