DATASHEET
Formulation
powder
Storage:
RT
Product Information:
Molecular Weight:206.22
Formula:C8H6N4OS
Purity:>98%
Solubility:Soluble in DMSO (up to 10 mg/ml with warming)
Chemical Name:N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide
Description:
Aquaporin 4 channel blocker, IC50 = 3.1 μM.1 Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI.2 Increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice.3 Reduces brain edema when administered after onset of ischemia in rat models.4