DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:306.12
Formula:C9H7IO2S
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).
Chemical Name:(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Description:
A selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices1. Displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death2. Some protective effects may be due to inhibition of MMP activity3.