DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:308.65
Formula:C12H6ClFN4O3
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 35 mg/ml)
Chemical Name:N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Description:
Potent and selective HIF-2α inhibitor, Kd=81 nM.1 Binds to the HIF-2α PAS-B domain2 and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2