bs-80301C
[Life Science]
FLI-06
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:438.52
Formula:C25H30N2O5
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Chemical Name:Cyclohexyl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
Formula:C25H30N2O5
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Chemical Name:Cyclohexyl-1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
Description:
FLI-06 was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER and is thus a novel agent acting at an early stage in secretory traffic (EC50=2.3 M)1. Abolishes MFAP5-dependent transcriptional programs which are upregulated in intrahepatic cholangiocarcinoma2. Suppresses proliferation and induces apoptosis in esophogeal squamous cell carcinoma cells3.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.