DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:292.81
Formula:C11H13ClO3S2
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Chemical Name:1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
Description:
Activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active in vivo.